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目的探讨舒芬太尼麻醉诱发患儿呛咳的影响因素。方法选取本院2010年7月在全身麻醉下行择期手术的2个月至15岁儿童197例,30 s内快速推注舒芬太尼1μg/kg,观察呛咳情况。对患儿的年龄、性别、体质量、身高、体表面积、舒芬太尼浓度和推注时间等可能影响呛咳的各种因素进行Logistic多元回归分析。结果多因素Logistic回归分析结果显示:性别、年龄、体质量、身高、体表面积和舒芬太尼浓度6个因素未发现是舒芬太尼诱发呛咳反应的影响因素,推注时间是舒芬太尼诱发呛咳的主要相关因素。不同推注时间,舒芬太尼诱发呛咳各反应强度差异无统计学意义(P>0.016)。结论舒芬太尼诱发儿童呛咳受推注时间的影响,延长舒芬太尼的推注时间、减慢给药速度,应是临床控制呛咳反应发生的首选措施。
Objective To investigate the influencing factors of choking induced by sufentanil in children. Methods A total of 197 children aged 2 months to 15 years undergoing selective elective surgery under general anesthesia in our hospital in July 2010 were enrolled in this study. Sufentanil 1 μg / kg was bolted within 30 seconds to observe the occurrence of choking. Logistic multiple regression analysis of various factors that may affect choking, such as age, sex, body weight, height, body surface area, concentration of sufentanil and time of injection in children. Results The results of multivariate Logistic regression analysis showed that sex, age, body weight, height, body surface area and concentration of sufentanil were not found to be the influencing factors of sufentanil-induced choking reaction. The injection time was sufentanil The main relevant factors that cause Tai Chi cough. There was no significant difference in the intensity of reaction between sufentanil and cough induced by different bolus injection time (P> 0.016). Conclusion Sufentanil-induced choking in children is influenced by the duration of bolus injection. Prolonging the bolus time and slowing down the administration of sufentanil should be the first choice for clinical control of choking reaction.