以人和鲑鱼降钙素为先导物 ,根据多肽类药物设计原理 ,借助多肽蛋白质计算机分析软件辅助设计了一种新的人降钙素类似物 ,简称新型降钙素 .计算机分析结果表明 :该新型降钙素等电点提高 (pI 8.7) ,C 末端亲水性增加 ,抗原表位分析图谱与人降钙素的相同 .利用基因工程法制备新型降钙素 ,并经Westernblotting分析表明它与人降钙素分子的抗原性相似 Taking human and salmon calcitonin as the lead, according to the design principles of polypeptide drugs, a new human calcitonin analogue, abbreviated as new calcitonin, was designed with the help of peptide protein computer analysis software.The results of computer analysis showed that the The new calcitonin isoelectric point increased (pI 8.7), C-terminal hydrophilic increased antigen epitope analysis of the same map and human calcitonin genetically engineered new calcitonin, and Westernblotting analysis showed that it with Human calcitonin molecules have similar antigenicity