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目的：探讨氧化苦参碱对实验性肝损伤肝胶原合成度及纤维化的影响。方法：采用ＣＣｌ４造成大鼠慢性肝损伤肝纤维化模型，同时用氧化苦参碱防治，并动态观察血清丙氨酸氨基转移酶（ＡＬＴ）、Ⅳ型胶原（Ⅳ－Ｃ）、透明质酸（ＨＡ）、肿瘤坏死因子－α（ＴＮＦα）的水平及肝组织病理变化，通过计算机图像分析系统分析肝内纤维组织增生情况。结果：氧化苦参碱治疗组血清ＡＬＴ，Ⅳ－Ｃ，ＨＡ，ＴＮＦα水平及肝组织内炎症活动度、纤维组织增生程度均低于模型组，且大剂量治疗组又低于小剂量治疗组。结论：氧化苦参碱有减轻肝脏炎症活动度、抑制肝内胶原合成度及抗肝纤维化作用。
Objective: To investigate the effect of oxymatrine on hepatic collagen synthesis and fibrosis in experimental liver injury. Methods: Chronic liver injury induced by CCl4 was induced by hepatic fibrosis in rats. At the same time, the rats were treated with oxymatrine. Serum alanine aminotransferase (ALT), collagen Ⅳ (Ⅳ-C), hyaluronic acid HA), tumor necrosis factor-α (TNFα) and pathological changes of liver tissue. The liver fibrosis was analyzed by computerized image analysis system. Results: Serum levels of ALT, Ⅳ-C, HA and TNFα in the oxymatrine treatment group were significantly lower than those in the untreated group. The levels of inflammatory activity and fibrosis in the liver tissue were lower in the oxymatrine treatment group than those in the low-dose treatment group. Conclusion: Oxymatrine can reduce hepatic inflammatory activity, inhibit hepatic collagen synthesis and prevent hepatic fibrosis.