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目的:探讨THP在早期非肌层侵润性膀胱癌定位诊断与治疗中的临床应用价值。方法:已诊断非肌层侵润性膀胱癌患者45例,术中均实行THP膀胱灌注,灌注后15min置入膀胱镜,观察膀胱内粘膜,将THP橙色染色区域作为实验组进行活检,其他未染色区域作为对照组随机活检,活检组织行病理检查。TUR-BT术后将45例患者随机分为3组,在不同的时间点开始灌注(术后即刻、术后6小时、术后7天),比较复发率和平均复发时间。结果:两组间比较具有统计学意义(P<0.05)恶性粘膜吸收THP敏感度和特异度分别为100%、63.5%;TUR-BT术后即刻灌注及6小时后灌注的总复发率明显低于术后7天灌注,差异有统计学意义(P<0.05)。结论:THP对非肌层侵润性膀胱癌早期定位诊断准确、安全性好,同时术后早期灌注THP可以降低肿瘤的复发率,值得临床推广。
Objective: To investigate the clinical value of THP in the diagnosis and treatment of early non-muscular invasion of bladder cancer. Methods: Forty-five patients with non-muscular bladder cancer were enrolled in the study. All the patients underwent THP intravesical instillation. Cystoscopy was performed at 15 min after perfusion, and the intramucosal mucosa was observed. The THP orange staining area was used as the experimental group for biopsy. Staining area as a control group random biopsy, biopsy tissue biopsy. After TUR-BT, 45 patients were randomly divided into 3 groups. Perfusion was started at different time points (immediately after operation, 6 hours after operation and 7 days after operation), and the relapse rate and mean recurrence time were compared. Results: The sensitivity and specificity of THP for THP in malignant mucosa were 100% and 63.5%, respectively. The total recurrence rate of TUR-BT immediate and 6-hour perfusion was significantly lower At 7 days after operation, the difference was statistically significant (P <0.05). Conclusion: THP is an accurate and safe method for early diagnosis of non-muscular invasion of bladder cancer. At the same time, THP can reduce the recurrence rate of tumor, which is worthy of clinical promotion.