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目的通过分析冠状动脉慢血流现象(CSFP,coronary slow flow phenomenon)与阻塞性睡眠呼吸暂停综合征(OSAS,obstructive sleep apnea syndrome)的各项指标,初步探讨CSFP发生的病理生理基础。方法回顾性分析我院2009年1月—2011年12月行冠脉造影发现冠状动脉慢血流现象并行夜间多导睡眠图(PSG,polysomnography)监测患者86例,分为非OSAS组58例(CSFP无OSAS组)、OSAS组28例(CSFP合并OSAS组)。计算2组患者校正的TIMI帧计数(cTFC,corrected TIMI frame count)。行PSG监测,记录年龄、性别、体质量指数(BMI)、睡眠呼吸暂停低通气指数(AHI)、血氧饱和度(SaO2)<90%的时间等参数。2组患者相关指数的比较采用2独立样本t检验,CSFP与AHI及SaO2<90%的相关性采用直线回归分析。结果 OSAS组的BMI为28.6±3.9,明显高于非OSAS组的24.7±5.0(P=0.005)。CSFP与AHI及SaO2<90%成正相关(r=0.627、0.584,P<0.05)。结论 CSFP与OSAS密切相关,同时cTFC与OSAS的严重程度相关。
OBJECTIVE: To investigate the pathophysiological basis of CSFP by analyzing the indexes of coronary artery slow flow phenomenon (CSFP) and obstructive sleep apnea syndrome (OSAS). Methods A retrospective analysis of our hospital from January 2009 -2011 December line coronary angiography found coronary artery slow flow phenomenon and concurrent night polysomnography (PSG, polysomnography) monitoring of patients with 86 cases were divided into 58 cases of non-OSAS group CSAS without OSAS group), OSAS group 28 cases (CSFP with OSAS group). The corrected TIMI frame count (cTFC, corrected TIMI frame count) was calculated for the two groups of patients. PSG monitoring was performed to record parameters such as age, gender, body mass index (BMI), sleep apnea-hypopnea index (AHI), and blood oxygen saturation (SaO2) <90%. Two groups of patients related index comparison using 2 independent samples t test, CSFP and AHI and SaO2 <90% correlation using linear regression analysis. Results The BMI of OSAS group was 28.6 ± 3.9, significantly higher than that of non-OSAS group (24.7 ± 5.0, P = 0.005). CSFP was positively correlated with AHI and SaO2 <90% (r = 0.627, 0.584, P <0.05). Conclusion CSFP is closely related to OSAS, while cTFC is associated with the severity of OSAS.