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目的了解上皮性卵巢癌患者血清前白蛋白（ｐｒｅａｌｂｕｍｉｎ，简称ＰＡ）水平与上皮性卵巢癌肿瘤生物学行为的关系及其作为上皮性卵巢癌生物学瘤标的意义。方法采用琼脂糖免疫单向扩散法测定５８例上皮性卵巢癌、３５例上皮性卵巢瘤和３０例正常人血清前白蛋白。同时用放免法测定上述检测对象血清ＣＡ１２５。结果上皮性卵巢癌组血清ＰＡ低于上皮性卵巢瘤组及正常人组（Ｐ＝０．００３）。且肿瘤临床分期越晚、分化越差，ＰＡ水平越低（Ｐ＜０．００１；Ｐ＝０．０２７），有淋巴转移者血清ＰＡ较无淋巴转移者低（Ｐ＜０．００１）；术后肿瘤残存与血清ＰＡ低水平有关（Ｐ＝０．０１４）。ＰＡ与ＣＡ１２５呈负相关，Ｓｐｅａｒｍａｎ′ｓ系数为—０．６８（Ｐ＜０．０１），ＰＡ越低ＣＡ１２５越高，与上皮性卵巢癌恶性生物学行为一致。结论ＰＡ与上皮性卵巢癌恶性行为密切相关，可作为上皮性卵巢癌病情及预后估计较敏感的新指标。
Objective To investigate the relationship between the serum prealbumin (PA) level and the biological behavior of epithelial ovarian cancer in patients with epithelial ovarian cancer and its significance as a biological marker of epithelial ovarian cancer. Methods 58 cases of epithelial ovarian cancer, 35 cases of epithelial ovarian tumor and 30 cases of normal serum prealbumin were detected by agarose immunization one-way diffusion method. At the same time using radioimmunoassay of serum CA125. Results The serum PA in epithelial ovarian cancer group was lower than that in epithelial ovarian tumor group and normal group (P = 0.003). The later the clinical stage was, the worse the differentiation was. The lower the level of PA was (P <0.001; P = 0.027). The serum PA in patients with lymphatic metastasis was lower than that without lymphatic metastasis (P <0.001) Residual tumor after the low level of serum PA (P = 0.014). PA was negatively correlated with CA125, Spearman’s coefficient was -0.68 (P <0.01). The lower the PA was, the higher the CA125 was. It was consistent with the malignant biological behavior of epithelial ovarian cancer. Conclusions PA is closely related to the malignant behavior of epithelial ovarian cancer and may be used as a new index to evaluate the prognosis and prognosis of epithelial ovarian cancer.