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报告了阿霉素磁性明胶微球（Ａｄｒ－ＭＧ－ｍｓ）的制备与性质，研究了超细氧化铁粒子的合成和磁性明胶微球（ＭＧ－ｍｓ）在狗体内的栓塞效果。阿霉素磁性明胶微球由２％阿霉素（Ａｄｒ）、６８％明胶和３０％的磁铁粒子组成，微球的平均粒径为２２μｍ。在体外实验中，药物释放速度证明微球有缓释的性质。磁铁粒子的平均粒径约为１０ｎｍ，磁性明胶微球与￣（９９ｍ）Ｔｃ标记磁性明胶微球通过导管分别输入狗的肝动脉内进行栓塞，照相和血管造影显示在未加外磁场时磁性明胶微球在左右肝叶分布几乎相等，而在１２００高斯的外磁场作用下，靶部位肝左叶的微球分布是肝右叶的２．２５倍，而甲状腺、脑、心脏的微球很微量，结果表明磁性明胶微球在外磁场作用下是一个很好的治疗肝癌的栓塞剂。
The preparation and properties of adriamycin magnetic gelatin microspheres (Adr-MG-ms) were reported. The synthesis of ultrafine iron oxide particles and the embolization effect of magnetic gelatin microspheres (MG-ms) in dogs were studied. Adriamycin magnetic gelatin microspheres consisted of 2% Adr, 68% gelatin and 30% magnetite particles with an average particle size of 22 μm. In in vitro experiments, the drug release rate proved that the microspheres have the property of sustained release. The average particle size of the magnet particles was about 10 nm. Magnetic gelatin microspheres and ~ (99m) Tc-labeled magnetic gelatin microspheres were transcatheter into the hepatic artery of dogs for embolization. Photographs and angiographs showed that magnetic gelatin The distribution of microspheres in the left and right hepatic lobe is almost equal. Under the effect of 1200 gauss external magnetic field, the distribution of microspheres in the left lobe of liver is 2.25 times that of the right lobe of the liver, while the amount of microspheres in the thyroid, brain and heart is very small , The results show that magnetic gelatin microspheres under the action of an external magnetic field is a good embolization agent for the treatment of liver cancer.