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恶性肿瘤包括肿瘤细胞的异质性,肿瘤干细胞(CSC)是具有高致瘤性和抗化疗特性的细胞群。这些细胞可以通过CSC标志物的表达来确定。有几种主要的干细胞标志物确切标志结肠癌,如CD133、CD44、ACDH1及ACCAM。目前,对癌症有效控制的主要阻碍是多药耐药(MDR)的发展,其主要机理是MDR表型是源于ABC转运蛋白的过度表达。肿瘤和治疗后的复发肿瘤是被具有积极耐药性的肿瘤细胞群所促进。这些细胞叫CSC或肿瘤启动细胞(TIC),在这里研究者们列举了近期有
Malignant tumors include the heterogeneity of tumor cells. Cancer stem cells (CSCs) are a group of cells that have high tumorigenicity and chemopreventive properties. These cells can be identified by the expression of CSC markers. There are several major stem cell markers that accurately identify colon cancers such as CD133, CD44, ACDH1, and ACCAM. Currently, the main obstacle to effective control of cancer is the development of multi-drug resistance (MDR), the main mechanism is that MDR phenotype is derived from the overexpression of ABC transporters. Tumors and post-treatment recurrent tumors are promoted by a population of tumor cells that are actively drug resistant. These cells are called CSCs or tumor-initiating cells (TICs), where researchers cite recent