运用免疫组织化学方法，使用抗Ｐ５３蛋白单克隆抗体ＤＯ－７，观察了２４８例肺癌组织中的Ｐ５３蛋白表达及分布特点。结果发现：①１３５例肺癌组织可见到Ｐ５３蛋白的表达，其频率为５４．４４％；②Ｐ５３蛋白表达呈异质性分布，有的癌组织Ｐ５３阳性染色细胞呈弥慢性分布，有的却呈点状分布，而且染色强度也有差异。这种分布特点可能与Ｐ５３的功能状态有关。③Ｐ５３蛋白表达与肺癌组织学类型及分化程度无明显相关性。 Using immunohistochemistry method, anti-P53 monoclonal antibody DO-7 was used to observe the expression and distribution of P53 protein in 248 lung cancer tissues. The results showed that the expression of P53 protein was observed in 1135 lung cancer tissues, with a frequency of 54.44%. The expression of P53 protein was heterogenously distributed. Some P53-positive cells stained for cancer showed a chronic distribution, some were spotted. Distribution, but also the intensity of staining. This distribution may be related to the functional status of P53. There was no significant correlation between the expression of 3P53 protein and the histological type and differentiation of lung cancer.