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PUVA治疗的副作用已报告的有光化性角化病,表皮细胞营养不良以及各种皮肤癌等.也有报告在PUVA治疗期间出现抗核抗体(ANA)滴度明显增高.据信,经PUVA治疗后的补骨脂素-DNA光加合物可激发ANA的产生.曾有病例报告,应用PUVA治疗银屑病与发生狼疮样综合征二者存在着时间上的联系,因此,这是令人关心的事.如果银屑病患者伴有亚临床的或未经诊断的SLE行PUVA治疗时,则有可能引起SLE恶化.为此,作者对269例用PUVA治疗,疗程为3月至7年的银屑病患者进行了随访,以观察ANA的变化.在此269例病人中,有13例(5%)开始ANA为阴性,后变为持续阳性;9例(3%)开始为阴性;后有一过性阳性;4例开始阳性,后为持续阳性;
Side effects of PUVA have been reported as actinic keratosis, epidermal cell dystrophy, and various skin cancers, etc. There has also been a report of a marked increase in antinuclear antibody (ANA) titer during PUVA treatment.It is believed that treatment with PUVA Post-psoralen-DNA photoadduct can stimulate ANA production. There have been case reports that the use of PUVA for the treatment of psoriasis and the occurrence of lupus-like syndrome exists in both time and, therefore, Concerned about the psoriasis patients with subclinical or without SLE line PUVA treatment, it may lead to deterioration of SLE.To this end, the authors of 269 cases with PUVA treatment, treatment period of 3 months to 7 years Of patients with psoriasis were followed up to observe changes in ANA, of which 13 (5%) of 269 patients started ANA-negative and then became consistently positive; nine (3%) started to be negative; After a transient positive; 4 cases started positive, after persistent positive;