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自主神经系统尤其是副交感神经对感冒时鼻分泌物增多等鼻症状的产生起重要作用。鼻内应用异丙阿托品则可以抑制乙酰胆硷攻击后造成的鼻分泌增强反应,并可缓解急性鼻炎、不明原因的感冒和常年性鼻炎的症状。但如阿托品用量过大,常会引起视力模糊或尿潴留。本文研究了健康人鼻腔对阿托品的耐受性并观察了接受鼻腔内鼻病毒接种的病人在鼻内应用硝酸甲基阿托品(AM)以后的症状变化情况,第一组实验于正常人鼻内应用AM250～500μg。每日4次,持续5天。对照组则使用安慰剂。结果应用AM的受试者发生了鼻干或全身性副
The autonomic nervous system, especially the parasympathetic nerve, plays an important role in the production of nasal symptoms such as the increase of nasal secretions during a cold. Intranasal administration of isoproterenol can inhibit the nasal secretion enhanced response to acetylcholine attack, and can alleviate the symptoms of acute rhinitis, unexplained cold and perennial rhinitis. However, if the amount of atropine is too large, often cause blurred vision or urinary retention. In this paper, the nasal cavity of healthy people was tested for tolerance to atropine and the symptoms of patients receiving intranasal rhinovirus inoculation after intranasal administration of methyl atropine (AM) were observed. The first group of experiments were conducted in normal subjects AM250 ~ 500μg. 4 times daily for 5 days. The control group received placebo. Results Subjects with AM developed nasal or systemic symptoms