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白血病及再生障碍性贫血的治疗也包括骨髓移植后的高剂量化疗,一般要结合抗肿瘤细胞的全身放疗以及免疫抑制治疗。这种调节性治疗方案接近几种组织的耐受量极限。严重急性与迟发性毒性可能主要在粘膜、胃肠道、肝、肺、膀胱、中枢神经系统发生。常用于调节性化疗的环磷酰胺会消耗肝脏的GSH,故潜在地启动过氧化过程。另外,据认为脂质过氧化是电离辐射损伤的主要原因之一。因此,调节性治疗方案的毒性可能部分是由于与辐射有关的组织损伤。作者研究调节性治疗是否对α-生育酚与β-胡萝卜素等抗氧化剂有影响。
Treatment of leukemia and aplastic anemia also includes high-dose chemotherapy after bone marrow transplantation, the general combination of anti-tumor cells, systemic radiation and immunosuppressive therapy. This accommodative regimen approaches the tolerance of several tissues. Serious acute and late toxicity may be mainly in the mucosa, gastrointestinal tract, liver, lung, bladder, central nervous system. Cyclophosphamide, which is commonly used in regulative chemotherapy, can consume the liver’s GSH, potentially activating the peroxidation process. In addition, it is believed that lipid peroxidation is one of the major causes of ionizing radiation damage. Therefore, the toxicity of regulatory regimens may be due in part to radiation-related tissue damage. The authors investigated whether conditioning regimens have an effect on antioxidants such as alpha-tocopherol and beta-carotene.