食管下端括约肌(LES)的调控机制是治疗胃食管反流性疾病的关键,而括约肌内参与调控的肠神经系统中各类神经及其递质的关系复杂。随着研究的深入,越来越多的神经被证实具有调节LES的功能。此文从病理组织学、神经生物学、药理学角度介绍各类神经研究情况。 Esophageal lower sphincter (LES) regulation mechanism is the key to the treatment of gastroesophageal reflux disease, and the sphincter involved in the regulation of the various types of nervous system and its neurotransmitter relationship is complicated. As research progresses, more and more nerves have been shown to regulate the function of LES. This article from the histopathology, neurobiology, pharmacology, describes various types of neurological research.