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目的探讨真菌感染的现状,预防和减少继发性真菌感染的发生。方法采用回顾性分析笔者所在医院2008年1月～2009年12月期间54例真菌感染患者的临床资料。结果真菌感染以60岁以上老年人居多,占74.07%,感染部位主要为呼吸道、泌尿道,所有患者发生真菌感染前均使用过抗菌药物,多数患者有严重的基础疾病,部分患者曾采用侵入性治疗。两性霉素B(AMB)和5-氟胞嘧啶(5-FC)具有较强抗真菌活性。结论高龄、严重基础疾病、广谱抗生素的大量应用、侵入性治疗是真菌感染的危险因素,合理使用抗生素是减少真菌感染的关键。
Objective To investigate the status of fungal infection and prevent and reduce the incidence of secondary fungal infections. Methods A retrospective analysis of the author’s hospital from January 2008 to December 2009 54 cases of fungal infections in patients with clinical data. Results The majority of fungal infections were elderly over the age of 60, accounting for 74.07%. The main infection sites were respiratory tract and urinary tract. Antifungal drugs were used in all patients before fungal infection. Most of the patients had severe underlying diseases and some patients had used invasive treatment. Amphotericin B (AMB) and 5-fluorocytosine (5-FC) have strong antifungal activity. Conclusion The elderly, severe underlying diseases, extensive use of broad-spectrum antibiotics, invasive treatment is a risk factor for fungal infections, rational use of antibiotics is the key to reduce fungal infections.