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目的:探索有效中草药对白色念珠菌抗菌作用。方法:采用菌基混合加药法、双倍稀释法体外测定8种中草药抗白色念珠菌作用的效果。结果:生大蒜汁、七叶一枝花有很强的抗白色念珠菌作用,其MIC分别为1.0mg/ml和1.5mg/ml,抗菌效价为3.12mg/ml和6.25mg/ml;丁香、一口钟其MIC均为2.0mg/ml,抗菌效价均为12.5mg/ml,表示抗菌作用较强;虎杖、土槿皮、木鳖子抗菌作用较弱,其MIC均为2.5mg/ml,抗菌效价为50mg/ml。结论:生大蒜汁、七叶一枝花、丁香、一口钟可用于治疗白色念珠菌所感染的疾病,但需进一步临床研究。
Objective: To explore the antibacterial effect of effective Chinese herbal medicine against Candida albicans. Methods: The effects of eight Chinese herbal medicines against Candida albicans were determined in vitro by using the mixed fungus method and double dilution method. RESULTS: Raw garlic juice and Aesculus japonica had a strong anti-Candida albicans effect. The MICs were 1.0 mg/ml and 1.5 mg/ml, respectively. The antibacterial potency was 3.12 mg/ml and 6.25 mg/ml. The MIC of each mouthpiece was 2.0 mg/ml, and the antibacterial potency was 12.5 mg/ml, indicating strong antibacterial activity; the antibacterial activity of Polygonum cuspidatum, Smilax glabra, and Scutellaria was weak, and the MICs were both 2.5 mg/ml. The antibacterial potency is 50 mg/ml. Conclusion: Raw garlic juice, Aesculus clove, Clove, and one bell can be used to treat diseases caused by Candida albicans, but further clinical research is needed.