论文部分内容阅读
心衰是一种常见的导致高死亡率的综合病症。它可能与因摄入饮食减少、胃肠水肿导致的蠕动减弱或使肠内锌吸收减少,进而使机体元素锌缺乏有关。伴随心衰的疾病糖尿病和高血压可能加剧锌缺乏。治疗心衰的药物可以不同形式影响锌代谢。已发现噻嗪类药物(利尿、降血压)可能导致锌尿和组织中锌减少。有不一致的证据表明,即使用慢性速尿治疗的患者尸体解剖时组织中锌水平降低。用血管紧张素转化酶抑制剂和血管紧张素受体阻滞剂治疗出现锌尿和锌缺乏,但这一结果和其他研究不相符。β-阻滞剂不改变血浆中锌浓度。基质金属蛋白酶和血管紧张素转化酶是含锌酶,在心衰改变过程中起作用。血管紧张素转化酶抑制剂可能抑制不同基质金属蛋白酶的活力。有必要研究在心衰、含锌酶、锌缺乏和HF临床表现间的相互关系。
Heart failure is a common syndrome that leads to high rates of death. It may be due to reduced intake of diet, gastrointestinal edema caused by decreased peristalsis or decreased intestinal absorption of zinc, thereby leaving the body of zinc deficiency. Diseases with heart failure Diabetes and high blood pressure can exacerbate zinc deficiency. Drugs that treat heart failure can affect zinc metabolism in different ways. It has been found that thiazide drugs (diuresis, hypotension) may result in loss of zinc and tissue zinc. There is inconsistent evidence that the level of zinc in the tissue is reduced even in autopsy of patients treated with chronic furosemide. Treatment with zinc oxide and zinc deficiency with angiotensin converting enzyme inhibitors and angiotensin receptor blockers did not match with other studies. Beta-blockers do not change the concentration of zinc in the plasma. Matrix metalloproteinases and angiotensin-converting enzymes are zinc-containing enzymes that play a role in heart failure processes. Angiotensin converting enzyme inhibitors may inhibit the activity of different matrix metalloproteinases. It is necessary to study the relationship between heart failure, zinc-containing enzymes, zinc deficiency and clinical manifestations of HF.