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目的比较溃疡性结肠炎患者、功能性胃肠功能紊乱患者和正常对照组的粪便中基质金属蛋白酶-9(MMP-9)水平,研究其与疾病活动性、钙卫蛋白的相关性。方法选取衢州市人民医院2012年-2013年UC患者48例,IBS-D患者25例,正常健康人25例进行研究,并用Mayo得分评价UC严重性,检测粪便MMP-9和钙卫蛋白,然后进行统计学分析。结果正常对照组和IBS-D患者粪便MMP-9低于检测限或低于0.22 ng/ml,UC患者粪便MMP-9与Mayo(P<0.001)、内镜检查(P<0.001)和CRP(P=0.002)得分明显相关。此外,UC患者MMP-9与粪便钙卫蛋白亦有一定的相关性(r=0.492,P=0.013)。结论粪便MMP-9可成为区别UC、IBS-D患者和正常对照组的一个非侵入的有用指标,并可用来判断疾病活动性。
Objective To compare the levels of matrix metalloproteinase-9 (MMP-9) in patients with ulcerative colitis, patients with functional gastrointestinal disorders and normal controls, and to investigate their association with disease activity and calprotectin. Methods 48 cases of UC patients, 25 cases of IBS-D patients and 25 healthy subjects were selected from Quzhou People’s Hospital from 2012 to 2013. UC severity was evaluated by Mayo score, stool MMP-9 and calprotectin were detected, and then Statistical analysis. Results The fecal MMP-9 levels in normal control and IBS-D patients were lower than the detection limit or lower than 0.22 ng / ml, and the levels of MMP-9 and Mayo in feces of UC patients (P <0.001), endoscopy P = 0.002) scores were significantly correlated. In addition, there was also a correlation between MMP-9 and calprotectin in UC patients (r = 0.492, P = 0.013). Conclusion Fecal MMP-9 can be a noninvasive and useful marker for distinguishing between UC and IBS-D patients and normal control group, and can be used to judge the disease activity.