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目的探讨并分析托吡酯与左乙拉西坦治疗儿童癫痫的疗效。方法本次研究所选对象为2013年2月~2014年2月到我院进行诊治的88例儿童癫痫病患儿,随机将其划分为A组和B组,两组病例分别为44例,其中A组采用托吡酯治疗,B组采用左乙拉西坦治疗,对比分析两组疗效。结果 A组治疗总有效率为90.9%,有5例患者发生不良反应,主要表现为低热、体重减轻、食欲不振以及脑力受损等;B组治疗有效率为88.7%,有6例患者发生不良反应,主要表现为食欲不振、易怒、无力以及低热等,两组在治疗总有效率和不良反应发生率上差异无统计学意义(P>0.05)。结论从本次研究的结果来看,托吡酯和左乙拉西坦治疗儿童癫痫的疗效差异不显著,在临床实践中,可结合患者自身病情实际情况来合理选用药物,以保证疗效。
Objective To investigate and analyze the efficacy of topiramate and levetiracetam in children with epilepsy. Methods 88 children with epilepsy were enrolled in our hospital from February 2013 to February 2014. The children were randomly divided into group A and group B. There were 44 cases in both groups, Among them, group A was treated with topiramate, group B was treated with levetiracetam, and the curative effect was compared between the two groups. Results The total effective rate of treatment in group A was 90.9%, and 5 patients had adverse reactions. The main adverse reactions were fever, weight loss, loss of appetite and mental damage. The effective rate of treatment in group B was 88.7%, and in 6 patients, Response, mainly manifested as loss of appetite, irritability, weakness and fever, the two groups in the treatment of total effective rate and the incidence of adverse reactions was no significant difference (P> 0.05). Conclusion From the results of this study, topiramate and levetiracetam in the treatment of children with epilepsy was no significant difference in clinical practice, patients with their own conditions may be the rational use of drugs to ensure efficacy.