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高血压的发病机制复杂,固定单片复方制剂利用不同降压机制的协同作用,达到快速高效的降压效果,不良反应少,患者依从性好,是临床高血压用药发展的趋势之一。通过检索近年来固定单片复方制剂治疗高血压的相关文献,分析总结目前临床常用的单片复方制剂,主要有利尿剂和血管紧张素Ⅱ受体阻滞药(ARB)或血管紧张素转换酶抑制剂(ACEI)组成的复方制剂、钙通道阻滞药(CCB)和ARB或ACEI组成的复方制剂、β受体阻滞剂与利尿剂组成的复方制剂等5类。
The pathogenesis of hypertension is complicated. The fixed monolithic compound takes advantage of the synergistic effect of different antihypertensive mechanisms to achieve rapid and effective antihypertensive effect with less adverse reactions and good patient compliance. It is one of the trends of the development of clinical antihypertensive drugs. Through searching the related literatures about the treatment of hypertension with fixed monolithic compound in recent years, the article summarizes the monotherapy commonly used in clinic, including diuretics and angiotensin Ⅱ blockers (ARB) or angiotensin converting enzyme (ACEI), compound of calcium channel blocker (CCB) and ARB or ACEI, and compound preparations of β-blocker and diuretic.