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目的了解胆汁淤积与母乳性黄疸的关系,并探讨茵枝黄对迟发型母乳性黄疸的疗效。方法①以50例诊断为迟发性母乳性黄疸的患儿为研究对象,并选取正常对照组40例,抽取静脉血测血清间接胆红素(IBIL)、血清总胆汁酸(TBA)、谷氨酰胺转肽酶(GGT)、碱性磷酸酶(ALP)、谷丙转氨酶(ALT)。②将50例迟发性母乳性黄疸患儿随机分为两组治疗,24例继续母乳喂养蓝光治疗(A组),26例茵枝黄加继续母乳喂养蓝光治疗(B组),并评价其疗效。结果①迟发性母乳性黄疸患儿的TBA、GGT、ALP较正常对照组明显升高(P<0.05)。②B组在血清间接胆红素下降程度及住院天数方面与A组有明显差异(P<0.05)。结论迟发型母乳性黄疸发病机制除了β-葡萄糖醛酸苷酶活性及数量增高外,还存在胆汁淤积。②借鉴该实验室依据使用茵枝黄治疗迟发型母乳性黄疸,可以减轻黄疸程度,减少住院时间。
Objective To understand the relationship between cholestasis and breast milk jaundice, and to explore the effect of Yanzhihuang on delayed-onset breast milk jaundice. Methods ①There were 50 children diagnosed as late-onset breast milk jaundice, and 40 normal control subjects were enrolled in this study. Serum indirect bilirubin (IBIL), serum total bile acid (TBA) Aminopeptidase (GGT), alkaline phosphatase (ALP), alanine aminotransferase (ALT). ②50 cases of delayed breast milk jaundice were randomly divided into two groups, 24 cases continued breast-feeding blue light treatment (group A), 26 cases of law yellow and breast-feeding blue light treatment (group B), and evaluated Efficacy. Results ① The levels of TBA, GGT and ALP in children with delayed breast milk jaundice were significantly higher than those in normal controls (P <0.05). ② There was a significant difference (P <0.05) between group B and group A in the degree of indirect bilirubin decline and length of hospital stay. Conclusion The pathogenesis of delayed-type breast milk jaundice in addition to β-glucuronidase activity and increased number, there is also cholestasis. ② Reference to the laboratory based on the use of Yin Zhi Huang treatment of delayed type of breast milk jaundice, can reduce the degree of jaundice, reduce hospital stay.