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本文报告了使用汉防已甲素和氮氧喹哌联合治疗猴实验性矽肺的结果,共用猴26只,分三个组,即汉防己甲素+氮氧喹哌组、汉甲组和氮氧喹哌组,各组分别设同期对照组,治疗时间均在12～14个月。根据X线变化,血清铜蓝蛋白及病理变化,肺干重,肺胶原、总脂、类脂、已糖的比较,表明联合用药组明显优于单独用药组。同时对用药后的毒副反应动态观察及毒性病理比较,联合用药组此单独用药组毒副作用更少。
This paper reports the results of the experimental treatment of experimental silicosis of monkeys with tetracycline and nifedipine in 26 monkeys, divided into three groups, ie, tetrandrine + nycloxamine group, haia group and nitrogen Oxyquiram group, each group were set the same period control group, the treatment time are in 12 to 14 months. According to X-ray changes, ceruloplasmin and pathological changes, lung dry weight, lung collagen, total fat, lipid, sugar have been compared, the combination group was significantly better than the single drug group. At the same time, the dynamic observation of toxic and side effects after treatment and the comparison of toxicology and pathology showed that there were fewer toxic side effects in the combination group.