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胸苷磷酸化酶(TP)是嘧啶和核苷代谢过程中的关键酶,近年发现其具有肿瘤血管新生作用,并与肿瘤病人的预后转归密切相关。同时TP还是5’-脱氧氟尿苷(5’-DFUR,商品名为氟铁龙)抑制肿瘤细胞生长的关键转化酶。目前,TP在结直肠癌细胞中是否表达尚无定论,但因其对肿瘤血管新生及增进5’-DFUR治疗效果的双重作用而倍受临床关注。文中对TP在结直肠癌组织中的表达与5’-DFUR细胞内激活、治疗的研究进展进行综述。
Thymidine phosphorylase (TP) is a key enzyme in pyrimidine and nucleoside metabolism. Recently, it has been found that it has tumor angiogenesis and is closely related to the prognosis of patients with cancer. At the same time, TP is also a key invertase that inhibits the growth of tumor cells by 5’-deoxyfluiduridine (5’-DFUR). At present, whether TP is expressed in colorectal cancer cells is inconclusive but is of clinical interest because of its dual effect on tumor angiogenesis and the promotion of 5’-DFUR treatment. In this paper, the expression of TP in colorectal cancer tissue and 5’-DFUR intracellular activation and treatment of research progress are reviewed.