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目的:对交泰丸中药配方颗粒剂与传统汤剂中盐酸小檗碱的溶出率进行比较,为临床中药剂型的选用提供依据。方法:采用高效液相色谱法,XTerraRP18色谱柱(4.6 mm×250 mm,5μm),流动相为0.05 mol.L-1磷酸二氢钾(用磷酸调pH至3.5)-乙腈(70∶30),流速为0.9 mL.min-1,检测波长为345 nm,柱温为35℃。结果:交泰丸中药配方颗粒剂与传统汤剂中盐酸小檗碱的相对溶出率分别为97.39%,85.21%。结论:中药配方颗粒组方时相互之间的影响可能要小于由饮片共煎而形成的传统汤剂。
OBJECTIVE: To compare the dissolution rates of Jiaotai Pills with those of traditional Chinese medicine in order to provide the basis for the selection of clinical dosage forms. METHODS: The mobile phase consisted of 0.05 mol·L-1 potassium dihydrogen phosphate (pH adjusted to 3.5 with phosphoric acid) -acetonitrile (70: 1) using HPLC on a XTerra® RP18 column (4.6 mm × 250 mm, 30) at a flow rate of 0.9 mL · min-1. The detection wavelength was 345 nm and the column temperature was 35 ℃. Results: The relative dissolution rates of Jiaotaiwan Chinese traditional medicine granule and traditional decoction berberine were 97.39% and 85.21% respectively. Conclusions: The effect of prescriptions of Chinese medicine granules on each other may be less than that of traditional decoctions formed by decocting pieces together.