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巨噬细胞电泳是Field与Caspary 1970年首次引用于肿瘤方面的一项技术。用从人脑组织中分出的硷性蛋白,即所谓脑源因子(EF),将脑源因子与肿瘤病人淋巴细胞共同培养,则淋巴细胞释放一种蛋白质,这种物质能使正常豚鼠巨噬细胞电泳减慢,故称为“巨噬细胞电泳缓慢因子”(MSF)。1971年他们又从人肿瘤组织中揭出一种硷性蛋白(CaBP)用以代EF作巨噬细胞电泳试验,则恶性疾病与一些神经组织损害病人之间有显著差异,而非恶性病人的淋巴细胞对此抗原则不敏感。随后,Pritchard等(1972、
Macrophage electrophoresis is the first technology Field and Caspary introduced in 1970 in oncology. Using alkaline protein, a so-called brain derived factor (EF), which is derived from human brain tissue, co-cultures brain derived factors with lymphocytes of tumor patients, the lymphocytes release a protein that allows normal guinea pig giant Phagocytic electrophoresis slowed, it is called “macrophage electrophoresis slow factor” (MSF). In 1971, they again revealed a basic protein (CaBP) from human tumor tissue to replace EF for macrophage electrophoresis test, and there was a significant difference between malignant disease and some patients with nerve tissue damage, but not from malignant patients Lymphocytes are not sensitive to this antigen. Subsequently, Pritchard et al. (1972,