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炎症的启动、发展、消退是受到促炎性介质及内源性促消退介质调控的一系列主动过程。继发现由花生四烯酸衍生的脂氧素及从炎症消退阶段的炎性渗出物中分离出由ω－3多不饱和脂肪酸转化而来的消退素与保护素后，在自我消退炎性渗出物和脂质调控介质中最近发现了一个新的有效的抗炎家族称为maresins。 maresins由内源性二十二碳六烯酸通过活化的巨噬细胞转化而成，在参与组织内环境平衡、炎症消退、切口愈合和减轻疼痛、机体防御等方面发挥有益的作用。“,”The initiation,development and resolution of inflammation is a series of active processes regu-lated by pro-inflammatory mediators and endogenous pro-resolving mediators.Following the discovery of the arachidonic acid-derived lipoxins and resolvin and protectin,converted from ω-3 polyunsaturated fatty acids isolated from the inflammatory exudate during inflammation subsiding stage , a new family of potent anti-inflammatory called maresins has been discovered in the inflammatory exudates and lipid mediators during subsiding stage.Maresins is converted from the endogenous DHA by stimulated macrophages,which plays a useful role in tissue environmental balance,inflammation subsiding,wound healing,pain relieving,and body defense.