有的抗血吸虫药物具有致癌和致突变作用,如吡喹酮和吡噻硫酮(oltipraz)能调节色氨酸代谢,使膀胱中致癌性色氨酸代谢物蓄积。由于肝脏是血吸虫感染严重影响的主要靶器官,以肝脏中的β-葡糖苷酸酶、核糖核酸酶、醋酸-α-萘酯酯酶三种溶酶体酶的活性,作为致癌性指数观察了曼氏血吸虫感染和抗血吸虫药吡喹酮和吡噻硫酮的影响。 Some anti-schistosome drugs have carcinogenic and mutagenic effects, such as praziquantel and oltipraz (oltipraz) can regulate tryptophan metabolism, the accumulation of carcinogenic tryptophan metabolites in the bladder. Since the liver is a major target organ that is seriously affected by schistosomiasis infection, the activity of three lysosomal enzymes of β-glucuronidase, ribonuclease and acetate-α-naphthyl ester esterase in the liver is observed as a carcinogenic index Schistosoma mansoni infection and anti-schistosomiasis praziquantel and oltipraz.