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目的探讨血浆内皮素(ET)和同型半胱氨酸(Hcy)与糖尿病性肾脏疾病(DKD)的关系。方法测定116例糖尿病(DM)患者和100名正常对照者(NC组)血浆ET、Hcy及尿白蛋白排泄率(UAER)。结果 DM无肾病组血浆ET和Hcy含量均高于NC组(P<0.05);微量白蛋白尿组与临床白蛋白尿组血浆ET和Hcy均与NC组比较有统计学差异(P<0.05)。相关性分析显示,临床白蛋白尿组血浆ET和Hcy与UAER呈正相关。结论血浆ET和Hcy的上升,可能反映DKD的进展。
Objective To investigate the relationship between plasma endothelin (ET) and homocysteine (Hcy) and diabetic nephropathy (DKD). Methods Plasma ET, Hcy and urinary albumin excretion (UAER) were measured in 116 diabetic patients and 100 normal controls (NC group). Results The levels of plasma ET and Hcy in DM without nephropathy group were significantly higher than those in NC group (P <0.05). The levels of plasma ET and Hcy in microalbuminuria group and clinical albuminuria group were significantly different from those in NC group (P <0.05) . Correlation analysis showed that there was a positive correlation between plasma ET and Hcy and UAER in clinical albuminuria group. Conclusions The rise of plasma ET and Hcy may reflect the progress of DKD.