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目的:探讨经皮冠状动脉介入治疗(PCI)前后冠心病患者血清胎盘生长因子水平变化及临床意义。方法:选择110例行择期PCI的冠心病患者,分别在术前,术后第1天、3天和5天测定血清胎盘生长因子(PlGF)水平;30例冠状动脉造影正常者作为对照。随访6个月,观察术后心血管事件(MACE)发生与PlGF水平变化之间的关系。结果:冠心病患者术后第1天血清胎盘生长因子水平均较术前增高[(14.49±3.42)∶(13.06±4.05)ng/L,P<0.01],术后第3天明显升高达到峰值[(16.44±3.25)∶(13.06±4.05)ng/L,P<0.01],术后第5天下降接近正常。发生MACE患者术前和术后血清PlGF峰值水平明显高于未发生MACE患者[(15.3±4.07)∶(10.7±2.65)ng/L,P<0.05)和(18.5±4.25)∶(12.3±3.28)ng/L,P<0.01)]。结论:冠心病患者PCI前后血清PlGF水平峰值与MACE相关,PlGF水平升高可能是冠心病患者PCI后发生MACE的危险因素之一。
Objective: To investigate the changes of serum levels of placental growth factor in patients with coronary heart disease before and after percutaneous coronary intervention (PCI) and its clinical significance. Methods: One hundred and ten patients with coronary artery disease undergoing elective PCI were enrolled. Serum placental growth factor (PlGF) levels were measured preoperatively, 1 day, 3 days and 5 days after surgery. Thirty patients with normal coronary arteries were selected as controls. After 6 months of follow-up, the relationship between postoperative cardiovascular events (MACE) and changes in the level of PlGF was observed. Results: The serum levels of placental growth factor on the first postoperative day in CHD patients were significantly higher than those before operation [(14.49 ± 3.42) vs (13.06 ± 4.05) ng / L, P <0.01] Peak value was (16.44 ± 3.25) (13.06 ± 4.05) ng / L, P <0.01], and the decrease was close to normal on the 5th day after operation. Preoperative and postoperative serum levels of PlGF in MACE patients were significantly higher than those in patients without MACE [(15.3 ± 4.07) vs (10.7 ± 2.65) ng / L, P <0.05) and (18.3 ± 3.28) ) ng / L, P <0.01)]. Conclusion: The peak value of serum PlGF level in patients with coronary heart disease before and after PCI correlates with MACE. Elevated PlGF level may be one of the risk factors of MACE in patients with coronary artery disease.