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目的:探讨舍曲林治疗消化性溃疡患者情绪障碍的临床疗效。方法:将60例消化性溃疡患者随机分为对照组(抑酸、抗菌、保护胃黏膜)和观察组(抑酸、抗菌、保护胃黏膜联合舍曲林)治疗8周。在治疗前、治疗2周末、治疗4周末、治疗8周末分别采用汉密尔顿抑郁量表(HAMD)评定情绪障碍临床疗效,并行统计分析比较。结果:在治疗2周时,两组疗效比较,观察组优于对照组(P=0.01),两组HAMD评分比较,存在显著差异(P<0.05)。在治疗8周末,两组HAMD评分比较有非常显著差异(P<0.01)。两组患者均无明显的不良反应发生。结论:舍曲林能明显改善消化性溃疡患者抑郁情绪,临床疗效肯定,安全性高。值得临床推广使用。
Objective: To investigate the clinical efficacy of sertraline in patients with peptic ulcer. Methods: Sixty patients with peptic ulcer were randomly divided into control group (acid suppression, antibacterial, protective gastric mucosa) and observation group (acid suppression, antibacterial, protective gastric mucosa combined with sertraline) for 8 weeks. Before treatment, 2 weeks after treatment, 4 weeks after treatment and 8 weeks after treatment, respectively. The Hamilton Depression Rating Scale (HAMD) was used to assess the clinical efficacy of mood disorders and statistical analysis was performed. Results: Compared with the control group (P = 0.01), the two groups had significant difference in HAMD score at 2 weeks (P <0.05). There was a significant difference in HAMD scores between the two groups at the end of 8 weeks of treatment (P <0.01). No significant adverse reactions occurred in both groups. Conclusion: Sertraline can significantly improve the depression of patients with peptic ulcer, clinical effect is sure, high safety. It is worth to promote clinical use.