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目的:分析原发性高血压患者血清瘦素及脂联素水平与肾素-血管紧张素的相关性,探讨血清瘦素及脂联素在原发性高血压发病中的病理生理机制。方法:原发性高血压组90例,其中24例为原发性高血压Ⅰ级,32例原发性高血压Ⅱ级,34例原发性高血压Ⅲ级,对照组56例,采用放射免疫方法测定血清瘦素、脂联素、血浆肾素(PRA)和血管紧张素Ⅱ(AngⅡ)浓度。结果:高血压组瘦素、PRA、AngⅡ均高于对照组(P<0.05),瘦素与PRA、AngⅡ正相关(P<0.01),而脂联素低于对照组(P<0.05),与PRA、AngⅡ负相关(P<0.01)。结论:原发性高血压的发生与血清瘦素、脂联素及肾素-血管紧张素水平有密切关系。
Objective: To analyze the correlation between serum leptin and adiponectin levels and renin-angiotensin system in patients with essential hypertension and to explore the pathophysiological mechanism of serum leptin and adiponectin in the pathogenesis of essential hypertension. Methods: 90 cases of essential hypertension group, of which 24 cases of primary hypertension Ⅰ, 32 cases of essential hypertension Ⅱ, 34 cases of essential hypertension Ⅲ grade, 56 cases of control group, using radiation Serum leptin, adiponectin, plasma renin (PRA) and angiotensin Ⅱ (AngⅡ) concentrations were measured by immunological methods. Results: The levels of leptin, PRA and AngⅡ in hypertension group were significantly higher than those in control group (P <0.05). The levels of leptin were positively correlated with PRA and AngⅡ (P <0.01) Negatively correlated with PRA and AngⅡ (P <0.01). Conclusion: The incidence of essential hypertension is closely related to the levels of serum leptin, adiponectin and renin - angiotensin.