论文部分内容阅读
目的：探讨灌胃不同剂量枸橼酸西地那非（sildenafil ciltrate,Sn；商品名Viagra）后对大鼠性行为的影响，为ED药物治疗后性行为的变化提供动物实验数据。方法24只雄性Wistar大鼠，随机分为阴性对照组（蒸馏水）、Sn中剂量组和高剂量组；灌胃Sn后与发情雌鼠1：1配对，观察记录60min内雄鼠的捕捉潜伏期、乘骑潜伏期、捕捉次数及乘骑次数等性行为变化。结果与阴性对照组相比，Sn中、高剂量组均能缩短捕捉及爬高潜伏期，增加捕捉及爬高次数（P＜0.01）；且有量效关系（P＜0.01）。结论 Sn在增加勃起功能的同时，能够显著增强雄鼠的捕捉潜伏期、乘骑潜伏期、捕捉次数及乘骑次数等性行为，可用于评价勃起功能药物的治疗效果。“,”Objective To observe the changes of sexual behaviours in male rats treated with Sildenafil Ciltrate through stomach irrigation and obtain the related experiment data for the treatment of ED.Methods A total of 24 males and 24 females, 4 months old Wistar rats were used in the study. The male rats were randomly divided into Group I (rats were treated with distilled water as the control), Group II and III( rats were treated with a dose of 10 mg/kg and20 mg/kg body weight Sildenafil Ciltrate, respectively). Then male and female rats were paired together. The sexual behavior of the male rats was observed in 60 minutes and recorded the following parameters: mount , intromission latency and mount , intromission frequency.Results Compared with that of the control, the mount and intromission latency were significantly shortened and the frequency were significantly increased (P<0.01), and moreover there was s dose-effect relationship (P<0.01).Conclusion Sildenafil Ciltrate significantly increased the erectile function as well as the sexual behaviours. It could be used to evaluate the treatment effect of erectile function drugs.