洛赛克是一种H~+—K~+ATP酶抑制剂。该药能使胃酸分泌减少,是治疗十二指肠溃疡、胃溃疡、反流性食管炎、卓-艾氏综合征的有效药物。洛赛克有两种剂型:胶囊剂和注射剂。注射剂包括冻干粉末和10ml氢氧化钠溶液。该溶液是作为溶媒使用的。目前临床上使用洛赛克针剂的方法多是将洛赛克粉末溶于10ml氢氧化钠溶液中,然后加到0.9％氯化钠溶液、10％葡萄糖、5％葡萄糖氯化钠等液体中滴注。这些用法均属欠妥。洛赛克是一个弱碱性化合物,pKa为4,其水溶液不稳定,易溶于碱,微溶于水,在 Losec is a H ~ + -K ~ + ATPase inhibitor. The drug can reduce gastric acid secretion, is the treatment of duodenal ulcer, gastric ulcer, reflux esophagitis, Zhuo - Ehrlich syndrome effective drugs. There are two types of Losec: capsules and injections. Injections include lyophilized powder and 10 ml of sodium hydroxide solution. This solution is used as a vehicle. At present, the method of using Losec injection in clinic is mostly to dissolve the Losec powder in 10 ml of sodium hydroxide solution and add it to a solution of 0.9% sodium chloride solution, 10% glucose, 5% glucose, sodium chloride and the like Note. These usage are all defects. Losec is a weakly basic compound, pKa of 4, its aqueous solution is unstable, soluble in alkali, slightly soluble in water, at