视网膜母细胞瘤是儿童中最常见的眼内恶性肿瘤。近年来,有关本病的遗传学已引起人们很大的兴趣与注意,1978年5月20～21日,东京召开了一次国际学术讨论会,专门讨论视网膜母细胞瘤,发表了多篇有关遗传学的论文,现从遗传学角度对此病作如下的讨论。一、遗传方式视网膜母细胞瘤的遗传方式有二类,一类属孟德尔遗传中的常染色体显性遗传方式,患者多有家族史存在,另一类为体细胞畸变,患者多以散发病例形式存在。Let-son研究了55个家谱,见5例有家族史存在,其它50例为散发病例,他例示了自己资料中的7个家谱,加用别人报导的一个典型 Retinoblastoma is the most common intraocular malignancy in children. In recent years, the genetics of this disease has aroused great interest and attention, Tokyo, May 20 ~ 21, 1978 held an international symposium devoted to retinoblastoma, published a number of articles on genetic Study papers, now from the genetic point of view of the disease to make the following discussion. First, the genetic mode Retinoblastoma genetic methods are two types, one belongs to the Mendelian inheritance of autosomal dominant inheritance, patients have more family history there, the other for somatic aberrations, patients with more sporadic cases Form exists. Let-son studied 55 pedigrees, of which five had family history, the other 50 were sporadic, and he instituted seven pedigrees in his own data, plus a model reported by others