论文部分内容阅读
采用XRD、DSC、体外降解实验和细胞相容性实验等方法对羟基磷灰石/聚醚酯聚氨酯(HA/PU)多孔支架的结构和性能进行了研究。结果表明,HA粒子添加到聚醚酯聚氨酯基体中,在一定程度上降低了聚氨酯软段的结晶,提高了聚氨酯基体的力学性能。体外降解实验表明HA/PU复合支架的降解不会引起浸泡液pH值较大的波动,且降解初期的力学性能衰减缓慢。MG63细胞与HA/PU复合支架共培养的实验表明,细胞生长良好,牢固地黏附在支架表面,并在支架表面充分伸展,复合支架具有良好的细胞相容性。这些结果表明HA/PU支架有望用于骨组织工程修复。
The structure and properties of hydroxyapatite / polyether ester polyurethane (HA / PU) porous scaffolds were studied by XRD, DSC, in vitro degradation experiments and cell compatibility experiments. The results show that the HA particles added to the polyether ester polyurethane matrix, to a certain extent, reduce the soft segment of polyurethane crystallization and improve the mechanical properties of the polyurethane matrix. In vitro degradation experiments showed that the degradation of HA / PU composite scaffold did not cause large fluctuations in the pH of the soaking solution, and the mechanical properties of the initial degradation of the HA / PU decay slowly. The experiments of co-culture of MG63 cells and HA / PU composite scaffolds showed that the cells grew well and adhered firmly to the surface of scaffolds and fully extended on the surface of scaffolds. The composite scaffolds had good cytocompatibility. These results indicate that HA / PU scaffolds are expected to be used in bone tissue engineering.