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目的:观察153钐-乙二胺四亚甲基膦酸(153Sm-EDTMP)联合甲孕酮(MPA)治疗多发性骨转移癌骨痛疗效、不良反应及对生活质量的影响。方法:入选32例,采用153Sm-EDTMP内照射联合MPA治疗。153Sm-EDTMP用法为2.96×107～3.70×107Bq·kg-1静注,4-6周用药1次,MPA 500mg·d-1,连用14d为1个疗程,共1～2个疗程。结果:完全缓解(CR)17例,部分缓解(PR)9例,缓解骨痛总有效为26例,对前列腺癌和乳腺癌骨转移患者 的有效率达到90%,患者的生活质量明显提高。主要不良反应为白细胞和血小板的轻、中度降低。结论:应用153 Sm-EDTMP联合MPA治疗多发性骨转移癌骨痛有效,不良反应小。
OBJECTIVE: To observe the curative effect, adverse reactions and quality of life of 154 patients with multiple bone metastases treated by 153 Sm-EDTMP combined with MPA. Methods: Thirty-two patients were enrolled and treated with 153Sm-EDTMP combined with MPA. 153Sm-EDTMP usage was 2.96 × 107 ~ 3.70 × 107Bq · kg-1 intravenous injection, 4-6 weeks medication 1, MPA 500mg · d-1, once every 14d for a course of treatment, a total of 1 to 2 courses. Results: 17 cases were completely relieved (CR), 9 cases were partial remission (PR) and 26 cases were relieved of bone pain. The effective rate was 90% for patients with bone metastases from prostate cancer and breast cancer, and the quality of life of patients was significantly improved. The main adverse reactions were mild and moderate reduction of white blood cells and platelets. CONCLUSION: 153 Sm-EDTMP combined with MPA is effective in treating bone pain with multiple bone metastases and little side effects.