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目的:观察赤雹果乙醇提取物(AETF)对子宫内膜炎继发性痛经的治疗作用。方法:采用大鼠子宫内植入塑料管法,诱发子宫内膜炎继发痛经模型。术后第2天开始灌胃(ig)给药,AETF低、中、高剂量(0.3,0.6,1.2 g.kg-1)连续7 d。以子宫的肿胀度,血液流变学(全血黏度、血浆黏度、红细胞聚集率)及子宫组织中PGE2含量为指标,观察AETF治疗继发性痛经的作用。结果:AETF 0.3,0.6,1.2 g.kg-1剂量组大鼠的子宫肿胀度、血浆黏度、红细胞聚集率均显著低于模型组(P<0.01或P<0.05);1.2 g.kg-1剂量组大鼠全血黏度显著低于模型组(P<0.01);0.6,1.2 g.kg-1剂量组大鼠子宫组织中的PGE2含量显著低于模型组(P<0.05)。结论:AETF治疗子宫内膜炎继发性痛经的作用与血液流变学指标的改善、子宫组织中PGE2含量的降低有关。
Objective: To observe the therapeutic effect of AETF on secondary dysmenorrhea of endometritis. Methods: The rats were intrauterine implantation of plastic tube method, induced endometritis secondary to dysmenorrhea model. Administered intragastrically (ig) on day 2 postoperatively. Low, medium and high doses of AETF (0.3, 0.6, 1.2 g.kg-1) were administered for 7 consecutive days. The effect of AETF on secondary dysmenorrhea was observed with the degree of uterine swelling, hemorheology (whole blood viscosity, plasma viscosity, erythrocyte aggregation rate) and the content of PGE2 in uterine tissue. Results: The uterine swelling degree, plasma viscosity and erythrocyte aggregation rate in AETF 0.3, 0.6 and 1.2 g.kg-1 groups were significantly lower than those in model group (P <0.01 or P <0.05) The whole blood viscosity of rats in the dose group was significantly lower than that in the model group (P <0.01). The contents of PGE2 in the uterus of 0.6 and 1.2 g.kg-1 groups were significantly lower than those in the model group (P <0.05). Conclusion: The effect of AETF on the treatment of secondary dysmenorrhea of endometritis is related to the improvement of hemorheology index and the decrease of PGE2 content in uterine tissue.