患者,女,28岁,因双下肢无力9年,双足下垂6年入院。患者于9年前渐出现双下肢行走无力,无力呈进行性加重,伴双小腿肌肉萎缩。6年前出现上楼、爬坡困难,行走时双下肢过度抬高,4年前出现下蹲后起立困难。病中无肢体麻木、肌肉跳动,无构音、吞咽困难及大小便障碍。神经系统查体:双手 Patient, female, 28 years old, with weakness due to both lower extremities 9 years, bipedal 6 years admitted to hospital. 9 years ago, patients gradually appear weak legs walking, weakness was progressive increase, with double calf muscle atrophy. 6 years ago appeared upstairs, climbing difficulties, excessive walking lower extremities, standing squat 4 years ago, standing up difficult. No limb numbness in the disease, muscle beating, no articulation, difficulty swallowing and urinary incontinence. Nervous system examination: hands