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目的:探讨中西医结合在白癜风患者中的临床疗效及安全性。方法:选取2014年2月至2016年2月中信惠州医院诊治的白癜风患者150例,根据治疗方法不同分为对照组和观察组各75例。对照组患者采用薄芝片、复合维生B片、泼尼松治疗,观察组联合紫黄中药配方颗粒治疗,比较两组患者的治疗效果及安全性。结果:两组患者治疗前皮损面积、色素积分比较,差异均无统计学意义(P>0.05);治疗后,两组患者的皮损面积、色素积分均优于治疗前,且观察组皮损面积显著小于对照组,色素积分显著高于对照组,差异具有统计学意义(P<0.05);观察组治疗后药物不良反应发生率为6.67%,显著低于对照组的16.00%,差异具有统计学意义(P<0.05);观察组复发率为4.0%,显著低于对照组的14.7%,差异具有统计学意义(P<0.05)。结论:白癜风患者采用中西医结合治疗效果理想,药物不良反应发生率较低。
Objective: To explore the clinical efficacy and safety of integrated traditional Chinese and western medicine in patients with vitiligo. Methods: A total of 150 patients with vitiligo diagnosed and treated by CITIC Huizhou Hospital from February 2014 to February 2016 were selected and divided into control group and observation group of 75 cases according to different treatment methods. Patients in the control group were treated with thin slice tablet, compound vitamin B tablet and prednisone, and the observation group was treated with the formulation of purple Chinese medicine granules. The therapeutic effect and safety of the two groups were compared. Results: There was no significant difference in lesion area and pigment integral between the two groups before treatment (P> 0.05). After treatment, the lesion area and pigment integral of the two groups were better than before treatment, (P <0.05). The incidence of adverse drug reactions in the observation group was 6.67%, which was significantly lower than that in the control group (16.00%), the difference was statistically significant (P <0.05). The recurrence rate in the observation group was 4.0%, which was significantly lower than that in the control group (14.7%), the difference was statistically significant (P <0.05). Conclusion: The treatment of vitiligo with Integrative Medicine is effective and the incidence of adverse drug reactions is low.