论文部分内容阅读
目的考察原位植烷三醇液晶的体外药物释放特点,评价其作为肝动脉介入治疗中化疗药物载体的可行性。方法以多西紫杉醇为模型药物,采用透析袋法考察处方组成、载药量、碘化油及释放条件对体外释放的影响,并考察此栓塞材料的弹性张力。结果原位植烷三醇液晶的体外释放行为符合Higuchi模型,摇床转速对释放无影响,但处方组成及载药量的改变均会引起药物释放速率的变化,且碘化油形成的外油相在一定程度上可缓解原位植烷三醇液晶的突释;另外,流变学结果显示,植烷三醇液晶可承受的最大压强为(3 070±2.135)Pa。结论原位植烷三醇液晶可缓释药物达30 d,抗压弹性较好,有望作为抗肿瘤药物载体应用于临床肝动脉介入治疗以取得局部化疗和物理栓塞的综合治疗效果。
Objective To investigate the in vitro drug release characteristics of phytantriol liquid crystal in situ and evaluate its feasibility as a chemotherapeutic drug carrier for hepatic artery interventional therapy. Methods Docetaxel was used as a model drug. The dialysis bag method was used to investigate the effects of formulation, drug loading, iodized oil and release conditions on in vitro release, and the elastic tension of this embolic material was investigated. Results The release behavior of in situ phytantriol liquid crystals in vitro was in accordance with Higuchi model. The rotational speed of the shaker had no effect on the release, but the composition of the prescription and the change of drug loading caused the change of drug release rate. Phase can relieve burst release of phytantriol liquid crystals in situ. In addition, the rheological results show that the maximum pressure at which phytantriol liquid crystal can withstand is (3 070 ± 2.135) Pa. CONCLUSION: In situ phytantriol liquid crystal can prolong drug release for up to 30 days and has good compressive elasticity. It is expected to be used as an antitumor drug carrier in clinical interventional treatment of hepatic artery in order to achieve the comprehensive therapeutic effect of local chemotherapy and physical embolization.