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目的:探讨前列腺囊腺瘤的临床病理特征。方法:应用常规病理、免疫组化方法观察1例前列腺囊腺瘤手术切除标本,结合相关临床资料及其病理特点进行分析,并复习文献。结果:患者男性,55岁,于1年前因排尿费力在外院行TUVP术。肿瘤大体为灰白色肿块,切面可见大小不等的囊腔,内充透明及浅白色液体。组织学特点:肿瘤呈筛状、微囊状或腺样排列,内衬覆立方上皮到柱状上皮细胞,细胞核位于基底部,无细胞异型性,无核分裂象。免疫表型:腺上皮表达PSA、PAP、CK7,而基底细胞34βE12阳性,CK20、P504S、CEA和绒毛蛋白均阴性,Ki67(+)<2%。结论:前列腺囊腺瘤是一种少见的前列腺来源的良性肿瘤,前列腺囊腺瘤在形态学上具有独特的组织结构,多表达PSA和PAP。
Objective: To investigate the clinicopathological features of prostate cystadenoma. Methods: One case of prostate cystadenoma underwent surgical resection by routine pathology and immunohistochemistry. The clinical data and pathological features were analyzed and reviewed. Results: The male patient, 55 years old, had a TUVP operation at the external hospital one year ago due to laborious urination. Tumor is generally white lumps, visible section of the cysts size, filled with transparent and light white liquid. Histological features: tumor was sieve-like, microencapsulated or gland-like arrangement, lined with cubic epithelium to the columnar epithelial cells, the nucleus located in the basal part, no cell atypia, no mitotic figure. Immunophenotype: PSA, PAP, and CK7 were expressed in the glandular epithelium, 34βE12 was positive in the basal cells, and both were negative for CK20, P504S, CEA and villi, with Ki67 (+) <2%. Conclusion: Prostatic cystadenoma is a rare benign tumor of prostate origin. Prostate cystadenoma has a unique morphological structure and expresses more PSA and PAP.