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高浓度组胺可激发CFU—S从Go期进入S期。这种效应可被10~(-5)M甲氰咪胍所拮抗。在有10~(-6)M甲苯苄二胺存在下,低浓度组胺也能促使CFU—S进入细胞周期。本文讨论了组胺对CFU—S细胞周期状态影响的意义及其可能机制。
High concentrations of histamine can stimulate CFU-S into the S phase from the Go. This effect can be 10 ~ (-5) M cimetidine antagonism. In the presence of 10 ~ (-6) M toluidine, low concentrations of histamine can also promote CFU-S into the cell cycle. This article discusses the significance of histamine on CFU-S cell cycle status and its possible mechanism.