【摘 要】
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Main observation and conclusionrnA facile copper-based catalytic system has been developed to enable efficient cyclization of methylketoximes and alkynals.This pro-tocol provides a viable entry to synthetically and pharmaceutically useful 2-acylpyrroles w
【机 构】
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Key Laboratory for Green Organic Synthesis and Application of Hunan Province,Key Laboratory of Envir
论文部分内容阅读
Main observation and conclusionrnA facile copper-based catalytic system has been developed to enable efficient cyclization of methylketoximes and alkynals.This pro-tocol provides a viable entry to synthetically and pharmaceutically useful 2-acylpyrroles with a broad range of compatible functionali-ties.Mechanistically,a key acyl migration is probably involved that leads to the formation of N-acyl pyrroles or otherwise NH pyrroles by further hydrolysis.More importantly,the present reaction system also gives an opportunity to realize three-component pyrrole assembly by simple addition of carboxylic acid.
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