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目的:评价倍青口腔溃疡液对口腔溃疡的作用。方法:采用化学烧灼法建立兔口腔溃疡模型,观察对口腔溃疡愈合的作用;通过巴豆油致小鼠耳廓肿胀试验模型和醋酸引起腹腔毛细血管通透性试验观察抗炎作用;采用小鼠扭体试验和热板法观察镇痛作用;采用临床常见病原菌进行倍青口腔溃疡液的体外抑菌试验。结果:倍青口腔溃疡液能促进家兔口腔溃疡愈合(P<0.05或0.01);缓解巴豆油所致小鼠耳廓肿胀(P<0.01);显著抑制小鼠腹腔毛细血管通透性(P<0.01);显著降低醋酸引起小鼠扭体反应次数,提高痛阈(P<0.05);有效抑制体外病原菌。结论:倍青口腔溃疡液具有抗炎、镇痛、抑菌等作用,对口腔溃疡具有良好的治疗及改善作用。
Objective: To evaluate the effect of timeslite oral ulcer fluid on oral ulcer. Methods: The model of oral ulcer in rabbits was established by chemical cauterization and the effect on the healing of oral ulcer was observed. The anti-inflammatory effect was observed by the mouse ear auricle swelling test induced by croton oil and acetic capillary induced peritoneal capillary permeability test. Body test and hot plate method to observe the analgesic effect; using common clinical pathogens to double blue oral ulcer fluid in vitro antibacterial test. Results: Beiqing oral ulcer fluid could promote the healing of oral ulcer in rabbits (P0.05 or 0.01), relieve the auricle swelling of mice induced by croton oil (P0.01), and significantly inhibit the peritoneal capillary permeability (P <0.01). The number of writhing reaction in mice induced by acetic acid was significantly decreased and the pain threshold was increased (P <0.05). The pathogen was effectively inhibited in vitro. Conclusions: Beiqing oral ulcer fluid has anti-inflammatory, analgesic and bacteriostatic effects and has good therapeutic and ameliorative effects on oral ulcer.