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目的探讨多西他赛在乳腺癌治疗中所致体液潴留的发生机制,为其预防和治疗提供策略。方法入组124例接受多西他赛治疗的乳腺癌患者,整理多西他赛所致体液潴留的发生率、预防及治疗方式。结果应用地塞米松预防后,124例患者中35例因多西他赛所致体液潴留,给予地塞米松联合呋塞米针治疗,29例症状消失,6例缓解。结论地塞米松预防多西他赛所致体液潴留效果肯定,地塞米松联合呋塞米针可治疗多西他赛所致的体液潴留。
Objective To investigate the mechanism of docetaxel in the treatment of breast cancer caused by fluid retention, to provide strategies for the prevention and treatment. Methods A total of 124 patients with breast cancer who underwent docetaxel treatment were enrolled in this study. The incidence, prevention and treatment of body fluid retention caused by docetaxel were collected. Results After dexamethasone prophylaxis, 35 of 124 patients were treated with docetaxel and furosemide because of docetaxel. The symptoms of 29 patients disappeared and 6 patients were relieved. Conclusion Dexamethasone is effective in preventing fluid retention caused by docetaxel. Dexamethasone combined with furosemide needle can treat the fluid retention caused by docetaxel.