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目前在干扰素(IFN)的临床应用研究方面,用于成人临床较多,而儿科临床的应用研究报道非常少。为了引起我国儿科临床工作者在医疗实践中重视干扰素的应用,本文综合了近几年部分文献资料提供临床医师参考。干扰素的简况IFN最初是从牛痘病毒感染兔的皮肤提取物中发现的,所以该病毒就成为诱生IFN的代表性物质。后来发现几乎所有病毒皆能诱生IFN,但以RNA病毒的诱生能力最强。除病毒外,许多人工合成的双股RNA,Poly 1:c及其衍生物,许多细菌及其某些产物,原虫和立克次体等都有诱生IFN的作用。
Currently in the clinical application of interferon (IFN) research, more clinical for adults, and pediatric clinical application of very few reports. In order to arouse the application of interferon to pediatric clinicians in our medical practice, this paper synthesizes some references in the past several years to provide clinician reference. Interferon Briefs IFNs were originally found in skin extracts from rabbits infected with vaccinia virus, so the virus became a representative substance inducing IFN. Later found that almost all of the virus can induce IFN, but RNA induced strongest ability of the virus. In addition to viruses, many synthetic double stranded RNAs, Poly 1: c and its derivatives, many bacteria and some of its products, protozoa and rickettsia, have the effect of inducing IFN.