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糖尿病并发血管性疾病的机制甚为复杂,其中内皮细胞损伤与血小板活化在该病的发生发展中起重要作用。我们观察von Willebrand因子(vWF)、血栓调节蛋白(sTM)、血浆可溶性内皮细胞蛋白C受体(sEPCR)和血小板颗粒膜蛋白-140(GMP-140)的变化,同时作为血管内皮细胞损伤和血小板活化的标记物,以糖尿病肾病(DN)作为血管病变的重要表达部位来研究两者的相关性,并对其临床意义进行探讨。 一、对象与方法 1.对象:52例人选者均为我院内分泌科住院2型糖尿病患者,空腹血糖(FBG)≥7.0 mmol/L,餐后血糖(PBG)≥11.1mmol/L,符合美国糖尿病协会(ADA)诊断标准。男28例,女24例,年龄
The mechanism of diabetes complicated with vascular diseases is very complicated, in which endothelial cell injury and platelet activation plays an important role in the occurrence and development of the disease. We observed the changes of von Willebrand factor (vWF), thrombomodulin (sTM), plasma soluble endothelial protein C receptor (sEPCR) and platelet granule membrane protein-140 (GMP-140) Activation of markers, diabetic nephropathy (DN) as an important expression of vascular lesions to study the correlation between the two, and to explore its clinical significance. I. Subjects and Methods 1. Subjects: All 52 patients were hospitalized in our department of endocrinology with type 2 diabetes mellitus, with fasting blood glucose (FBG) ≥7.0 mmol / L and postprandial blood glucose (PBG) ≥11.1 mmol / L, in line with the United States Diabetes Association (ADA) diagnostic criteria. 28 males and 24 females, age