为探讨大蒜对口腔癌前病变的预防作用及其机制，将３２只Ｗｉｓｔａｒ大白鼠随机分为二组。大蒜组大鼠硬腭粘膜涂大蒜注射液，对照组涂等量蒸馏水；随后涂４－硝基喹啉氧化物；每周３次，共１３周。结果显示，大蒜能有效地预防口腔癌前病变发生，且提示这种预防作用与大蒜提高自然杀伤细胞活性，改善Ｔ细胞功能及提高白细胞介素－２水平有关。 To explore the preventive effect and mechanism of garlic on oral precancerous lesions, 32 Wistar rats were randomly divided into two groups. In the garlic group, the hard palate mucosa was coated with garlic, and the control group was coated with equal amount of distilled water; then 4-nitroquinoline oxide was applied; 3 times per week for 13 weeks. The results showed that garlic can effectively prevent the occurrence of oral precancerous lesions, and suggested that this preventive effect is related to garlic to increase natural killer cell activity, improve T cell function, and increase interleukin-2 levels.