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心脏肥大是心肌细胞对高血压、瓣膜病、急性心肌梗死及先天性心脏病等常见临床疾病的一种基本应答,是影响心血管疾病病死率和发病率的独立危险因素,其发病机制中信号转导通路的研究是当前研究热点。凋亡信号调节激酶1是有丝分裂原激活蛋白激酶的上游激酶,参与细胞的生长、分化、凋亡,近年来研究发现它与心脏肥大的发生也存在密切关系。
Cardiac hypertrophy is a basic response of cardiomyocytes to common clinical diseases such as hypertension, valvular disease, acute myocardial infarction and congenital heart disease. It is an independent risk factor affecting the mortality and morbidity of cardiovascular diseases. The signal of pathogenesis The study of transduction pathways is the current research hotspot. Apoptosis signaling-regulated kinase 1 is an upstream kinase of mitogen-activated protein kinase and is involved in the growth, differentiation and apoptosis of cells. In recent years, it has been found that cardiac kinase 1 is closely related to the occurrence of cardiac hypertrophy.