论文部分内容阅读
目的:探讨超声血流动力学改变对婴儿肝炎综合征(婴肝征)肝纤维化程度的诊断价值。方法:用超声检测41例婴肝征及70例健康婴儿肝脏血流动力学,并对41例婴肝征行肝病理检查,并按病理肝纤维化程度分组进行单因素方差分析和相关分析。结果:41例行肝活检或手术患儿主要病理改变以肝纤维结缔组织增生最常见,占39例次(95.1%),S1~S3者24例,S者15例。肝固有动脉(PHA)收缩期峰值速度(Vs)、舒张末期流速(Vd)、阻力指数(RI)测值和PHAVs/PVVmax在轻、中、重度肝纤维化组逐渐增高,Vs、RI、PHAVs/PVVmax与肝纤维化程度呈正相关(r分别为0.719和0.748,0.700,P<0.001);肝静脉(HV)多普勒频谱波形与肝纤维化程度亦呈正相关(r=0.787,P<0.001)。结论:超声检测PHA的Vs、RI和PHAVs/PVVmax,以及HV多普勒频谱波形改变是反映婴肝征肝纤维化程度较敏感的指标。
Objective: To investigate the diagnostic value of ultrasonic hemodynamic changes on the degree of liver fibrosis in infantile hepatitis syndrome (infantile liver syndrome). Methods: The hemodynamics of 41 cases of infants with liver signs and 70 cases of healthy infants were detected by ultrasound. Liver pathology was performed on 41 cases of infants. One-way ANOVA and correlation analysis were made according to the degree of pathological liver fibrosis. Results: The main pathological changes of 41 patients with liver biopsy or surgery were the most common pathological changes of liver fibrosis, accounting for 39 cases (95.1%), 24 cases of S1 ~ S3, and 15 cases of S. The peak systolic velocity (Vs), end-diastolic velocity (Vd), resistance index (RI) and PHAVs / PVVmax of hepatic artery (PHA) increased gradually in mild, moderate and severe hepatic fibrosis group. Vs, RI, PHAVs / PVVmax was positively correlated with the degree of liver fibrosis (r = 0.719 and 0.748,0.700, respectively, P <0.001). The Doppler spectral waveform of hepatic vein (HV) was positively correlated with the degree of liver fibrosis (r = 0.787, ). Conclusion: The changes of Vs, RI, PHAVs / PVVmax, and HV Doppler waveforms in PHA by ultrasound are the sensitive indexes to reflect the degree of liver fibrosis in infants.