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目的探讨惠州市HIV/AIDS患者抗病毒疗效及CD4+T淋巴细胞变化特征,为艾滋病治疗提供依据。方法选择接受国家免费抗病毒治疗1年内的病例,用回顾性队列研究法,分析不同治疗时间的CD4细胞计数结果。结果共调查HIV/AIDS治疗病例196人,以青壮年为主,性别比2.1∶1。治疗3个月后,患者CD4细胞计数<50个/μL占比大幅下降,占比最高为200~349个/μL,治疗6、9和12个月后,占比最高均为≥350个/μL。治疗基线与治疗3个月、治疗3个月与6个月前后CD4细胞计数增加显著。治疗1年,CD4基线≥200个/μL组CD4细胞上升更显著。结论惠州市HIV/AIDS患者抗病毒治疗疗效显著,但部分患者仍可能面临产生耐药毒株以及治疗失败的危险。应尽早保持长期规范治疗,达到真正的免疫重建。
Objective To investigate the anti-virus efficacy and the characteristics of CD4 + T lymphocyte subsets in HIV / AIDS patients in Huizhou and provide evidence for the treatment of AIDS. Methods The patients who received free antiviral therapy within one year in our country were selected and retrospective cohort study was used to analyze the CD4 count of different treatment time. Results A total of 196 HIV / AIDS cases were investigated, mainly young adults, with a sex ratio of 2.1: 1. After 3 months of treatment, the proportion of patients with CD4 counts <50 / μL dropped significantly, accounting for the highest proportion of 200 to 349 / μL. After 6, 9 and 12 months, the highest proportion was ≥350 / μL. Treatment baseline and treatment of 3 months, 3 months and 6 months after treatment, CD4 cell count increased significantly. Treatment for 1 year, CD4 baseline ≥ 200 / μL group of CD4 cells increased more significantly. Conclusion The anti-virus treatment of HIV / AIDS patients in Huizhou is significant, but some patients may still be at risk of drug-resistant strains and treatment failure. Long-term standardized treatment should be maintained as soon as possible to achieve a true immune reconstruction.